Multimarker method in the study of laboratory predictors of vascular wall elasticity as the basis for the development of a personalized approach to the treatment of socially significant diseases

Abstract Funding Acknowledgements Type of funding sources: None. Aim To investigate the role markers vascular inflammation, vitamin D, parathyroid hormone as predictors increased pulse-wave velocity (PWV) and degenerative bone changes in postmenopausal women with arterial hypertension (AH). Methods 164 females were examined. Gr.1 included 42 healthy individuals, Gr.2 - 58 patients AH Gr.3 64 osteoporosis. Parameters blood pressure monitoring; PWV, osteodensitometry (T-Score); inflammatory markers: hsCRP, TNFα, homocysteine, IL-1β, 6, 8, endothelin-1; lipid profile parameters; sex hormones, D measured. Results In excess levels IL8, total cholesterol, LDL endothelin-1 was detected decrease level hormones D. Besides, negative correlations T-Score age, duration menopause, IL-6, hsCRP registered; positive between PWV IL6, endothelin-1, DBP variability found. The logistic regression method revealed main that affect increase such endothelin-1.Rise each marker by unit measurement leads to 1.3 times 2.4%, respectively. more than 12.05 m/s associated 3.8-fold risk on 1 6 fold Conclusions Elevated are hormone, may be part pathogenesis cardiovascular continuum women, which will require an individual approach treatment comorbid metabolic disorders.